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Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior

Overview of attention for article published in Biological Research, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#33 of 492)
  • Good Attention Score compared to outputs of the same age (77th percentile)

Mentioned by

twitter
7 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
121 Mendeley
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1 CiteULike
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Title
Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior
Published in
Biological Research, March 2016
DOI 10.1186/s40659-016-0076-5
Pubmed ID
Authors

Ignacio Negrón-Oyarzo, Ariel Lara-Vásquez, Ismael Palacios-García, Pablo Fuentealba, Francisco Aboitiz

Abstract

Schizophrenia is a severe psychiatric disorder that results in a significant disability for the patient. The disorder is characterized by impairment of the adaptive orchestration of actions, a cognitive function that is mainly dependent on the prefrontal cortex. This behavioral deficit, together with cellular and neurophysiological alterations in the prefrontal cortex, as well as reduced density of GABAergic cells and aberrant oscillatory activity, all indicate structural and functional deficits of the prefrontal cortex in schizophrenia. Among the several risk factors for the development of schizophrenia, stress during the prenatal period has been identified as crucial. Thus, it is proposed that prenatal stress induces neurodevelopmental alterations in the prefrontal cortex that are expressed as cognitive impairment observed in schizophrenia. However, the precise mechanisms that link prenatal stress with the impairment of prefrontal cortex function is largely unknown. Reelin is an extracellular matrix protein involved in the development of cortical neural connectivity at embryonic stages, and in synaptic plasticity at postnatal stages. Interestingly, down-regulation of reelin expression has been associated with epigenetic changes in the reelin gene of the prefrontal cortex of schizophrenic patients. We recently showed that, similar to schizophrenic patients, prenatal stress induces down-expression of reelin associated with the methylation of its promoter in the rodent prefrontal cortex. These alterations were paralleled with altered prefrontal cortex functional connectivity and impairment in prefrontal cortex-dependent behavioral tasks. Therefore, considering molecular, cellular, physiological and behavioral evidence, we propose a unifying framework that links prenatal stress and prefrontal malfunction through epigenetic alterations of the reelin gene.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Unknown 120 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 26 21%
Student > Ph. D. Student 21 17%
Student > Master 17 14%
Researcher 11 9%
Student > Postgraduate 8 7%
Other 13 11%
Unknown 25 21%
Readers by discipline Count As %
Neuroscience 33 27%
Agricultural and Biological Sciences 15 12%
Medicine and Dentistry 14 12%
Biochemistry, Genetics and Molecular Biology 10 8%
Psychology 8 7%
Other 9 7%
Unknown 32 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2018.
All research outputs
#3,702,631
of 19,327,386 outputs
Outputs from Biological Research
#33
of 492 outputs
Outputs of similar age
#62,447
of 274,291 outputs
Outputs of similar age from Biological Research
#1
of 1 outputs
Altmetric has tracked 19,327,386 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 492 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,291 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them