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Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review

Overview of attention for article published in Lipids in Health and Disease, March 2016
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Title
Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review
Published in
Lipids in Health and Disease, March 2016
DOI 10.1186/s12944-016-0221-8
Pubmed ID
Authors

Xiao-Lin Li, Jian-Qing Sui, Lin-Lin Lu, Nan-Nan Zhang, Xin Xu, Quan-Yong Dong, Yong-Ning Xin, Shi-Ying Xuan

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which represents a wide spectrum of hepatic damage. Several studies have reported that NAFLD is a strong independent risk factor for coronary artery disease (CAD). And patients with NAFLD are at higher risk and suggested undergoperiodic cardiovascular risk assessment. Cardiovascular disease (CVD) is responsible for the main cause of death in patients with NAFLD, and is mostly influenced by genetic factors. Both NAFLD and CAD are heterogeneous disease. Common pathways involved in the pathogenesis of NAFLD and CAD includes insulin resistance (IR), atherogenic dyslipidemia, subclinical inflammation, oxidative stress, etc. Genomic characteristics of these two diseases have been widely studied, further research about the association of these two diseases draws attention. The gene polymorphisms of adiponectin-encoding gene (ADIPOQ), leptin receptor (LEPR), apolipoprotein C3 (APOC3), peroxisome proliferator-activated receptors (PPAR), sterol regulatory elementbinding proteins (SREBP), transmembrane 6 superfamily member 2 (TM6SF2), microsomal triglyceride transfer protein (MTTP), tumor necrosis factors-alpha (TNF-α) and manganese superoxide dismutase (MnSOD) have been reported to be related to NAFLD and CAD. In this review, we aimed to provide an overview of recent insights into the genetic basis of NAFLD and CAD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 1%
Unknown 68 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 19%
Researcher 11 16%
Student > Bachelor 10 14%
Student > Doctoral Student 5 7%
Other 4 6%
Other 13 19%
Unknown 13 19%
Readers by discipline Count As %
Medicine and Dentistry 23 33%
Biochemistry, Genetics and Molecular Biology 11 16%
Agricultural and Biological Sciences 9 13%
Nursing and Health Professions 3 4%
Immunology and Microbiology 3 4%
Other 4 6%
Unknown 16 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2016.
All research outputs
#18,447,592
of 22,856,968 outputs
Outputs from Lipids in Health and Disease
#983
of 1,448 outputs
Outputs of similar age
#218,346
of 300,113 outputs
Outputs of similar age from Lipids in Health and Disease
#21
of 35 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,448 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.