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MicroRNA biogenesis and their functions in regulating stem cell potency and differentiation

Overview of attention for article published in Biological Procedures Online, March 2016
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Title
MicroRNA biogenesis and their functions in regulating stem cell potency and differentiation
Published in
Biological Procedures Online, March 2016
DOI 10.1186/s12575-016-0037-y
Pubmed ID
Authors

Shaomian Yao

Abstract

Stem cells are unspecialized/undifferentiated cells that exist in embryos and adult tissues or can be converted from somatic differentiated cells. Use of stem cells for tissue regeneration and tissue engineering has been a cornerstone of the regenerative medicine. Stem cells are also believed to exist in cancer tissues, namely cancer stem cells (CSCs). Growing evidence suggests that CSCs are the culprit of cancer dormancy, progression and recurrence, and thus have recently received great attention. MicroRNAs (miRNAs) are a group of short, non-coding RNAs that regulate expression of a wide range of genes at a post-transcriptional manner. They are emerging as key regulators of stem cell behaviors. This mini review summarizes the basic biogenesis and mode of actions of miRNAs, recent progress and discoveries of miRNAs in cellular reprogramming, stem cell differentiation and cellular communication, as well as miRNAs in CSCs. Some potential of miRNAs in future biomedical applications and research pertaining to stem cells are briefly discussed.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 112 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 18%
Student > Master 15 13%
Student > Bachelor 12 11%
Student > Doctoral Student 10 9%
Researcher 8 7%
Other 19 17%
Unknown 28 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 43 38%
Agricultural and Biological Sciences 18 16%
Medicine and Dentistry 10 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Immunology and Microbiology 2 2%
Other 7 6%
Unknown 29 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2016.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Biological Procedures Online
#171
of 192 outputs
Outputs of similar age
#271,066
of 314,759 outputs
Outputs of similar age from Biological Procedures Online
#4
of 4 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 192 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,759 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.