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Prognostic value of microRNA-21 in pancreatic ductal adenocarcinoma: a meta-analysis

Overview of attention for article published in World Journal of Surgical Oncology, March 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

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3 tweeters

Citations

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18 Dimensions

Readers on

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37 Mendeley
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Title
Prognostic value of microRNA-21 in pancreatic ductal adenocarcinoma: a meta-analysis
Published in
World Journal of Surgical Oncology, March 2016
DOI 10.1186/s12957-016-0842-4
Pubmed ID
Authors

Geng-yuan Hu, Feng Tao, Wei Wang, Ke-wei Ji

Abstract

Recently, microRNA-21 (miR-21) has been reported to be associated with prognosis of pancreatic ductal adenocarcinoma (PDAC). The present studies aimed to evaluate the prognostic value of miR-21 for PDAC with meta-analysis. A systematic search in the PubMed and other databases was conducted to identify eligible studies. The pooled hazard ratios (HRs) with 95 % confidence interval (CI) were calculated. The meta-analysis was conducted using the STATA 12.0 software. A total of 12 articles (13 studies) which included 963 cases were selected for the meta-analysis. Elevated miR-21 expression was significantly predictive of poor overall survival (HR = 2.05, 95 % CI 1.71-2.46, P < 0.001). In the subgroup analyses, similar results were observed in Asian (HR = 2.09, 95 % CI 1.62-2.71, P < 0.001) and Caucasian (HR = 2.36, 95 % CI 1.53-3.65, P < 0.001); in tissue sample (HR = 2.14, 95 % CI 1.73-2.65, P < 0.001) and serum sample (HR = 1.84, 95 % CI 1.30-2.60, P = 0.001); with quantitative real-time polymerase chain reaction assay method (HR = 2.31, 95 % CI 1.86-2.86, P < 0.001); and in patients receiving adjuvant chemotherapy (HR = 2.37, 95 % CI 1.88-3.00, P < 0.001). The association between miR-21 expression level and lymph node metastasis was statistically significant (OR = 1.45, 95 % CI 1.02-2.06, P = 0.038). However, no significant relationship between miR-21 expression level and sex or vascular invasion or neural infiltration was observed (P > 0.05). Our meta-analysis indicated that elevated miR-21 expression level can predict poor prognosis in patients with PDAC.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 19%
Researcher 6 16%
Student > Bachelor 6 16%
Other 3 8%
Student > Doctoral Student 3 8%
Other 7 19%
Unknown 5 14%
Readers by discipline Count As %
Medicine and Dentistry 15 41%
Biochemistry, Genetics and Molecular Biology 7 19%
Nursing and Health Professions 3 8%
Agricultural and Biological Sciences 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 3 8%
Unknown 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2016.
All research outputs
#3,066,216
of 7,401,456 outputs
Outputs from World Journal of Surgical Oncology
#147
of 1,184 outputs
Outputs of similar age
#110,791
of 276,720 outputs
Outputs of similar age from World Journal of Surgical Oncology
#1
of 42 outputs
Altmetric has tracked 7,401,456 research outputs across all sources so far. This one has received more attention than most of these and is in the 57th percentile.
So far Altmetric has tracked 1,184 research outputs from this source. They receive a mean Attention Score of 1.3. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,720 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.