Title |
Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis
|
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Published in |
Retrovirology, March 2016
|
DOI | 10.1186/s12977-016-0249-x |
Pubmed ID | |
Authors |
Guangyong Ma, Jun-ichirou Yasunaga, Masao Matsuoka |
Abstract |
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus responsible for the development of adult T-cell leukemia (ATL). Although HTLV-1 harbors an oncogene, tax, that transforms T cells in vitro and induces leukemia in transgenic mice, tax expression is frequently disrupted in ATL, making the oncogenesis of ATL a bit mysterious. The HTLV-1 bZIP factor (HBZ) gene was discovered in 2002 and has been found to promote T-cell proliferation and cause lymphoma in transgenic mice. Thus HBZ has become a novel hotspot of HTLV-1 research. This review summarizes the current findings on HBZ with a special focus on its potential links to the oncogenesis of ATL. We propose viewing HBZ as a critical contributing factor in ATL development. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Israel | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 80 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 21 | 26% |
Student > Ph. D. Student | 11 | 13% |
Researcher | 11 | 13% |
Student > Master | 10 | 12% |
Student > Postgraduate | 5 | 6% |
Other | 12 | 15% |
Unknown | 12 | 15% |
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---|---|---|
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Medicine and Dentistry | 13 | 16% |
Agricultural and Biological Sciences | 13 | 16% |
Immunology and Microbiology | 11 | 13% |
Nursing and Health Professions | 4 | 5% |
Other | 6 | 7% |
Unknown | 12 | 15% |