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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The diagnostic accuracy of the hand-held Raman spectrometer for the identification of anti-malarial drugs
|
|---|---|
| Published in |
Malaria Journal, March 2016
|
| DOI | 10.1186/s12936-016-1212-y |
| Pubmed ID | |
| Authors |
Benjamin J. Visser, Sophia G. de Vries, Emmanuel B. Bache, Janneke Meerveld-Gerrits, Daniëlle Kroon, Jimmy Boersma, Selidji T. Agnandji, Michèle van Vugt, Martin P. Grobusch |
| Abstract |
There is a need for accurate and field-applicable instruments for the evaluation of the quality of anti-malarial drugs. The aim of this study was to determine the diagnostic accuracy of the NanoRam(®), a handheld Raman spectrometer (RS), to identify anti-malarial drugs. In total, 289 anti-malarial drugs collected in a randomized field survey in Gabon were evaluated. The samples were compared with authentic products as supplied by the official manufacturer. To determine the sensitivity and specificity of the handheld NanoRam(®) spectrometer in the identification of anti-malarial drugs, a two-gate reversed-flow design was applied. The standards for reporting of diagnostic accuracy studies (STARD) were followed. The index test was the handheld RS. The reference test standards were thin layer chromatography and high performance liquid chromatography with ultraviolet photo diode array detection. The sensitivity [95 % confidence interval (95 % CI)] and specificity of the RS to correctly identify an anti-malarial drug were 100 % (95 % CI 94.9-100 %) and 96 % (95 % CI 92.3-99.0 %), respectively. The RS could not differentiate between different batches of the same product or different manufacturers of the same product. Intra-observer agreement for 289 samples was 100 %. The average time to conduct the RS was 15 s per sample compared to 45 min per sample for TLC. The handheld RS holds promise as an easy-to-use, quick and field-applicable instrument for the evaluation of quality of anti-malarial drugs, potentially empowering pharmacists, drug inspectors and medical regulatory authorities. Trial registration NTR4341 (Dutch Trial Registry). |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 2% |
| Unknown | 41 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 24% |
| Researcher | 8 | 19% |
| Student > Bachelor | 4 | 10% |
| Professor > Associate Professor | 3 | 7% |
| Student > Ph. D. Student | 3 | 7% |
| Other | 6 | 14% |
| Unknown | 8 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 14% |
| Medicine and Dentistry | 4 | 10% |
| Economics, Econometrics and Finance | 3 | 7% |
| Engineering | 3 | 7% |
| Other | 9 | 21% |
| Unknown | 8 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2016.
All research outputs
#7,476,657
of 22,856,968 outputs
Outputs from Malaria Journal
#2,458
of 5,573 outputs
Outputs of similar age
#106,772
of 299,392 outputs
Outputs of similar age from Malaria Journal
#77
of 193 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,573 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,392 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 193 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.