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All-you-can-eat: autophagy in neurodegeneration and neuroprotection

Overview of attention for article published in Molecular Neurodegeneration, January 2009
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  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
2 tweeters

Citations

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139 Dimensions

Readers on

mendeley
243 Mendeley
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Title
All-you-can-eat: autophagy in neurodegeneration and neuroprotection
Published in
Molecular Neurodegeneration, January 2009
DOI 10.1186/1750-1326-4-16
Pubmed ID
Authors

Philipp A Jaeger, Tony Wyss-Coray

Abstract

Autophagy is the major pathway involved in the degradation of proteins and organelles, cellular remodeling, and survival during nutrient starvation. Autophagosomal dysfunction has been implicated in an increasing number of diseases from cancer to bacterial and viral infections and more recently in neurodegeneration. While a decrease in autophagic activity appears to interfere with protein degradation and possibly organelle turnover, increased autophagy has been shown to facilitate the clearance of aggregation-prone proteins and promote neuronal survival in a number of disease models. On the other hand, too much autophagic activity can be detrimental as well and lead to cell death, suggesting the regulation of autophagy has an important role in cell fate decisions. An increasing number of model systems are now available to study the role of autophagy in the central nervous system and how it might be exploited to treat disease. We will review here the current knowledge of autophagy in the central nervous system and provide an overview of the various models that have been used to study acute and chronic neurodegeneration.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 243 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
United Kingdom 2 <1%
Australia 2 <1%
Japan 2 <1%
Mexico 2 <1%
Canada 2 <1%
Netherlands 1 <1%
India 1 <1%
Turkey 1 <1%
Other 0 0%
Unknown 225 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 62 26%
Researcher 42 17%
Student > Bachelor 34 14%
Student > Master 24 10%
Professor > Associate Professor 16 7%
Other 50 21%
Unknown 15 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 111 46%
Medicine and Dentistry 33 14%
Neuroscience 31 13%
Biochemistry, Genetics and Molecular Biology 29 12%
Engineering 4 2%
Other 13 5%
Unknown 22 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2021.
All research outputs
#11,109,539
of 19,302,634 outputs
Outputs from Molecular Neurodegeneration
#554
of 746 outputs
Outputs of similar age
#72,409
of 134,844 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 7 outputs
Altmetric has tracked 19,302,634 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 746 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 134,844 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.