Title |
RETRACTED ARTICLE: MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling
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Published in |
Journal of Experimental & Clinical Cancer Research, March 2016
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DOI | 10.1186/s13046-016-0323-1 |
Pubmed ID | |
Authors |
Shao-Jun Chu, Ge Wang, Peng-Fei Zhang, Rui Zhang, Yan-Xia Huang, Yun-Min Lu, Wei Da, Qun Sun, Jing Zhang, Jin-Shui Zhu |
Abstract |
MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive. Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression. MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 29% |
Other | 1 | 7% |
Student > Bachelor | 1 | 7% |
Student > Master | 1 | 7% |
Researcher | 1 | 7% |
Other | 1 | 7% |
Unknown | 5 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 29% |
Chemistry | 2 | 14% |
Nursing and Health Professions | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Other | 0 | 0% |
Unknown | 5 | 36% |