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Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro

Overview of attention for article published in BMC Pulmonary Medicine, July 2015
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3 tweeters

Citations

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28 Dimensions

Readers on

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39 Mendeley
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Title
Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro
Published in
BMC Pulmonary Medicine, July 2015
DOI 10.1186/s12890-015-0070-7
Pubmed ID
Authors

Jonas Christian Schupp, Sandrine Tchaptchet, Niklas Lützen, Peggy Engelhard, Joachim Müller-Quernheim, Marina A Freudenberg, Antje Prasse

Abstract

Propionibacterium acnes was found in lungs and lymph nodes of patients with sarcoidosis and may induce hypersensitivity type granuloma formation. Data regarding the immune response to P. acnes of European sarcoid patients are scarce. We assessed the total IgG and IgA amount and specific antibodies to P. acnes and to Staphylococcus aureus, serving as a control, in BAL fluid of 64 patients with sarcoidosis and of 21 healthy volunteers. In a subcohort of sarcoid patients and controls, TNF-α and GM-CSF production of BAL cells stimulated with heat-killed P. acnes were measured. In sarcoid patients, the total IgG and IgA levels in BAL fluid were significantly elevated compared to healthy volunteers. IgG and IgA titres against P. acnes and S. aureus were increased in sarcoid patients, yet based on the total amount of antibodies, only antibodies directed against P. acnes were relatively and significantly increased. Furthermore, BAL cells of sarcoid patients produced significantly more TNF-α and GM-CSF upon stimulation with heat-killed P. acnes compared to controls. Patients with sarcoidosis had elevated levels of specific antibodies against P. acnes which suggest contact with this bacterium in the past. Furthermore, BAL cells of sarcoid patients produced inflammatory cytokines (TNF-α and GM-CSF) upon stimulation with P. acnes indicating potential involvement of this pathogen in the pathogenesis of sarcoidosis in some patients.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 21%
Student > Ph. D. Student 7 18%
Student > Doctoral Student 3 8%
Student > Bachelor 3 8%
Other 3 8%
Other 7 18%
Unknown 8 21%
Readers by discipline Count As %
Medicine and Dentistry 14 36%
Immunology and Microbiology 10 26%
Agricultural and Biological Sciences 4 10%
Computer Science 1 3%
Veterinary Science and Veterinary Medicine 1 3%
Other 1 3%
Unknown 8 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2022.
All research outputs
#13,534,662
of 21,702,786 outputs
Outputs from BMC Pulmonary Medicine
#786
of 1,774 outputs
Outputs of similar age
#145,183
of 279,496 outputs
Outputs of similar age from BMC Pulmonary Medicine
#1
of 1 outputs
Altmetric has tracked 21,702,786 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,774 research outputs from this source. They receive a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,496 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them