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Hsp90 depletion goes wild

Overview of attention for article published in BMC Biology, February 2012
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Hsp90 depletion goes wild
Published in
BMC Biology, February 2012
DOI 10.1186/1741-7007-10-14
Pubmed ID

Mark L Siegal, Joanna Masel


Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation. See research article http://wwww.biomedcentral.com/1471-2148/12/25.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Portugal 1 2%
Unknown 55 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 24%
Researcher 9 16%
Student > Master 8 14%
Professor 7 12%
Student > Bachelor 5 9%
Other 11 19%
Unknown 4 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 57%
Biochemistry, Genetics and Molecular Biology 15 26%
Arts and Humanities 1 2%
Environmental Science 1 2%
Immunology and Microbiology 1 2%
Other 2 3%
Unknown 5 9%