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Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases

Overview of attention for article published in BMC Urology, March 2016
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3 X users

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Title
Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases
Published in
BMC Urology, March 2016
DOI 10.1186/s12894-016-0129-7
Pubmed ID
Authors

Zhaohui Chen, Jayoung Kim

Abstract

Assays of molecular biomarkers in urine are non-invasive compared to other body fluids and can be easily repeated. Based on the hypothesis that the secreted markers from the diseased organs may locally release into the body fluid in the vicinity of the injury, urine-based assays have been considered beneficial to monitoring bladder health and urological diseases. The urine proteome is much less complex than the serum and tissues, but nevertheless can contain biomarkers for diagnosis and prognosis of diseases. The urine metabolome has a much higher number and concentration of low-molecular metabolites than the serum or tissues, with a far lower lipid concentration, yet informs directly about dietary and microbial metabolism. We here discuss the use of mass spectrometry-based proteomics and metabolomics for urine biomarker assays, specifically with respect to the underlying mechanisms that trigger the pathological condition. Molecular biomarker profiles, based on proteomics and metabolomics studies, reliably distinguish patients from healthy controls, stratify sub-populations with respect to treatment options, and predict therapeutic response of patients with urological disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
United Kingdom 1 1%
Unknown 73 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 17%
Researcher 11 15%
Student > Master 7 9%
Student > Doctoral Student 6 8%
Student > Bachelor 6 8%
Other 16 21%
Unknown 16 21%
Readers by discipline Count As %
Medicine and Dentistry 18 24%
Biochemistry, Genetics and Molecular Biology 8 11%
Agricultural and Biological Sciences 8 11%
Chemistry 5 7%
Engineering 4 5%
Other 9 12%
Unknown 23 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2016.
All research outputs
#14,842,329
of 22,856,968 outputs
Outputs from BMC Urology
#371
of 751 outputs
Outputs of similar age
#170,254
of 300,114 outputs
Outputs of similar age from BMC Urology
#3
of 4 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 751 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,114 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.