Title |
Apoptosis inhibition or inflammation: the role of NAIP protein expression in Hodgkin and non-Hodgkin lymphomas compared to non-neoplastic lymph node
|
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Published in |
Journal of Inflammation, February 2012
|
DOI | 10.1186/1476-9255-9-4 |
Pubmed ID | |
Authors |
Safoura Mazrouei, Amin Ziaei, Amir Pouya Tanhaee, Kianoosh Keyhanian, Mahdad Esmaeili, Azar Baradaran, Mansoor Salehi |
Abstract |
Inhibitors of Apoptosis (IAP) family play a critical role in apoptosis and inflammatory response. Neuronal Apoptosis Inhibitory Protein (NAIP), as a member of both IAPs and NLR families (NOD-Like Receptor), is a unique IAP harboring NOD (Nucleotide Oligomerization Domain) and LLR (Leucine Rich Repeat) motifs. Considering these motifs in NAIP, it has been suggested that the main function of NAIP is distinct from other members of IAPs. As a member of NLR, NAIP mediates the assembly of 'Inflammasome' for inflammatory caspase activation. Pathologic expression of NAIP has been reported not only in some infectious and inflammatory diseases but also in some malignancies. However, there is no report to elucidate NAIP expression in lymphomatic malignancies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 4% |
Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 30% |
Other | 4 | 17% |
Student > Ph. D. Student | 3 | 13% |
Professor > Associate Professor | 2 | 9% |
Student > Doctoral Student | 1 | 4% |
Other | 2 | 9% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 35% |
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Medicine and Dentistry | 3 | 13% |
Neuroscience | 1 | 4% |
Chemistry | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 22% |