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The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration

Overview of attention for article published in Neural Development, March 2016
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Mentioned by

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2 tweeters

Citations

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35 Dimensions

Readers on

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57 Mendeley
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Title
The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration
Published in
Neural Development, March 2016
DOI 10.1186/s13064-016-0063-0
Pubmed ID
Authors

Brock Grill, Rodney K. Murphey, Melissa A. Borgen

Abstract

During development, a coordinated and integrated series of events must be accomplished in order to generate functional neural circuits. Axons must navigate toward target cells, build synaptic connections, and terminate outgrowth. The PHR proteins (consisting of mammalian Phr1/MYCBP2, Drosophila Highwire and C. elegans RPM-1) function in each of these events in development. Here, we review PHR function across species, as well as the myriad of signaling pathways PHR proteins regulate. These findings collectively suggest that the PHR proteins are intracellular signaling hubs, a concept we explore in depth. Consistent with prominent developmental functions, genetic links have begun to emerge between PHR signaling networks and neurodevelopmental disorders, such as autism, schizophrenia and intellectual disability. Finally, we discuss the recent and important finding that PHR proteins regulate axon degeneration, which has further heightened interest in this fascinating group of molecules.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 55 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 26%
Researcher 15 26%
Student > Master 7 12%
Student > Bachelor 4 7%
Student > Doctoral Student 3 5%
Other 6 11%
Unknown 7 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 21%
Agricultural and Biological Sciences 10 18%
Neuroscience 9 16%
Nursing and Health Professions 3 5%
Medicine and Dentistry 3 5%
Other 7 12%
Unknown 13 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2016.
All research outputs
#3,383,945
of 7,435,912 outputs
Outputs from Neural Development
#53
of 137 outputs
Outputs of similar age
#126,304
of 275,322 outputs
Outputs of similar age from Neural Development
#4
of 7 outputs
Altmetric has tracked 7,435,912 research outputs across all sources so far. This one has received more attention than most of these and is in the 52nd percentile.
So far Altmetric has tracked 137 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,322 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.