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WldS but not Nmnat1 protects dopaminergic neurites from MPP+neurotoxicity

Overview of attention for article published in Molecular Neurodegeneration, February 2012
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Title
WldS but not Nmnat1 protects dopaminergic neurites from MPP+neurotoxicity
Published in
Molecular Neurodegeneration, February 2012
DOI 10.1186/1750-1326-7-5
Pubmed ID
Authors

Jo Ann V Antenor-Dorsey, Karen L O'Malley

Abstract

The WldS mouse mutant ("Wallerian degeneration-slow") delays axonal degeneration in a variety of disorders including in vivo models of Parkinson's disease. The mechanisms underlying WldS -mediated axonal protection are unclear, although many studies have attributed WldS neuroprotection to the NAD+-synthesizing Nmnat1 portion of the fusion protein. Here, we used dissociated dopaminergic cultures to test the hypothesis that catalytically active Nmnat1 protects dopaminergic neurons from toxin-mediated axonal injury.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 8%
United Kingdom 1 3%
Belgium 1 3%
Australia 1 3%
Unknown 31 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 27%
Student > Ph. D. Student 8 22%
Student > Bachelor 3 8%
Student > Postgraduate 3 8%
Professor 2 5%
Other 4 11%
Unknown 7 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 46%
Neuroscience 4 11%
Biochemistry, Genetics and Molecular Biology 3 8%
Nursing and Health Professions 2 5%
Medicine and Dentistry 1 3%
Other 3 8%
Unknown 7 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2012.
All research outputs
#20,155,513
of 22,663,150 outputs
Outputs from Molecular Neurodegeneration
#828
of 842 outputs
Outputs of similar age
#224,070
of 247,689 outputs
Outputs of similar age from Molecular Neurodegeneration
#21
of 22 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 842 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,689 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.