Title |
Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
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Published in |
BMC Genomics, February 2012
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DOI | 10.1186/1471-2164-13-62 |
Pubmed ID | |
Authors |
Bridget M Barker, Kristin Kroll, Martin Vödisch, Aurélien Mazurie, Olaf Kniemeyer, Robert A Cramer |
Abstract |
Aspergillus fumigatus is a mold responsible for the majority of cases of aspergillosis in humans. To survive in the human body, A. fumigatus must adapt to microenvironments that are often characterized by low nutrient and oxygen availability. Recent research suggests that the ability of A. fumigatus and other pathogenic fungi to adapt to hypoxia contributes to their virulence. However, molecular mechanisms of A. fumigatus hypoxia adaptation are poorly understood. Thus, to better understand how A. fumigatus adapts to hypoxic microenvironments found in vivo during human fungal pathogenesis, the dynamic changes of the fungal transcriptome and proteome in hypoxia were investigated over a period of 24 hours utilizing an oxygen-controlled fermenter system. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | <1% |
France | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Croatia | 1 | <1% |
Unknown | 154 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 38 | 24% |
Researcher | 25 | 16% |
Student > Doctoral Student | 15 | 9% |
Student > Bachelor | 15 | 9% |
Student > Master | 12 | 8% |
Other | 25 | 16% |
Unknown | 29 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 58 | 36% |
Biochemistry, Genetics and Molecular Biology | 35 | 22% |
Immunology and Microbiology | 16 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
Chemical Engineering | 2 | 1% |
Other | 8 | 5% |
Unknown | 38 | 24% |