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Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis

Overview of attention for article published in BMC Pharmacology and Toxicology, March 2016
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Title
Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis
Published in
BMC Pharmacology and Toxicology, March 2016
DOI 10.1186/s40360-016-0054-0
Pubmed ID
Authors

H. Kitt, W. Lenney, F. J. Gilchrist

Abstract

Chronic infection with Burkholderia cepacia complex (BCC) has a detrimental effect on morbidity and mortality for patients with cystic fibrosis (CF). It is therefore logical to attempt to eradicate new isolates however there is a paucity of information to guide treatment. We report the successful eradication of new isolates of BCC in two children with CF. Burkholderia cepacia was successfully eradicated in a 14 year old boy with CF and Burkholderia gladioli was successfully eradicated in a six year old girl with CF. In both children two weeks of intravenous (IV) tobramycin, ceftazidime and temocillin were used followed by three months of inhaled tobramycin. Bronchoalveolar lavage samples taken during flexible bronchoscopy were used prior to treatment to exclude spontaneous clearance as well as after treatment to confirm eradication. New isolates of BCC can be successfully eradicated in children with CF. More research is urgently required in this area to identify the best treatment regimen for BCC eradication.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 13%
Other 3 10%
Student > Ph. D. Student 3 10%
Student > Bachelor 3 10%
Student > Doctoral Student 2 7%
Other 7 23%
Unknown 8 27%
Readers by discipline Count As %
Medicine and Dentistry 10 33%
Biochemistry, Genetics and Molecular Biology 4 13%
Immunology and Microbiology 4 13%
Agricultural and Biological Sciences 2 7%
Nursing and Health Professions 1 3%
Other 2 7%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2016.
All research outputs
#19,941,677
of 25,371,288 outputs
Outputs from BMC Pharmacology and Toxicology
#323
of 483 outputs
Outputs of similar age
#220,070
of 315,683 outputs
Outputs of similar age from BMC Pharmacology and Toxicology
#8
of 10 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 483 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,683 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.