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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Single-CpG resolution mapping of 5-hydroxymethylcytosine by chemical labeling and exonuclease digestion identifies evolutionarily unconserved CpGs as TET targets
|
|---|---|
| Published in |
Genome Biology, March 2016
|
| DOI | 10.1186/s13059-016-0919-y |
| Pubmed ID | |
| Authors |
Aurélien A. Sérandour, Stéphane Avner, Elise A. Mahé, Thierry Madigou, Sylvain Guibert, Michaël Weber, Gilles Salbert |
| Abstract |
Conventional techniques for single-base resolution mapping of epigenetic modifications of DNA such as 5-hydroxymethylcytosine (5hmC) rely on the sequencing of bisulfite-modified DNA. Here we present an alternative approach called SCL-exo which combines selective chemical labeling (SCL) of 5hmC in genomic DNA with exonuclease (exo) digestion of the bead-trapped modified DNA molecules. Associated with a straightforward bioinformatic analysis, this new procedure provides an unbiased and fast method for mapping this epigenetic mark at high resolution. Implemented on mouse genomic DNA from in vitro-differentiated neural precursor cells, SCL-exo sheds light on an intrinsic lack of conservation of hydroxymethylated CpGs across vertebrates. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| United Kingdom | 2 | 29% |
| Brazil | 1 | 14% |
| France | 1 | 14% |
| Spain | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 57% |
| Scientists | 2 | 29% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| France | 1 | 2% |
| Unknown | 50 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 26% |
| Student > Ph. D. Student | 14 | 26% |
| Student > Master | 6 | 11% |
| Student > Bachelor | 4 | 8% |
| Other | 4 | 8% |
| Other | 9 | 17% |
| Unknown | 2 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 24 | 45% |
| Agricultural and Biological Sciences | 19 | 36% |
| Neuroscience | 2 | 4% |
| Chemistry | 2 | 4% |
| Computer Science | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 2 | 4% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2016.
All research outputs
#8,261,140
of 25,371,288 outputs
Outputs from Genome Biology
#3,444
of 4,467 outputs
Outputs of similar age
#110,724
of 315,337 outputs
Outputs of similar age from Genome Biology
#72
of 79 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,337 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.