Title |
Stem Cell Transplantation for Primary Immunodeficiency Disease: Experience of a Singapore Hospital
|
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Published in |
World Allergy Organization Journal, March 2012
|
DOI | 10.1097/wox.0b013e31824af5e3 |
Pubmed ID | |
Authors |
Alison Joanne Lee, Jethro Wu, Mariflor Sarmiento Villegas, Lynette Pei-Chi Shek, Bee-Wah Lee, Poh-Lin Tan |
Abstract |
We retrospectively analyzed the outcomes of hematopoietic stem cell transplantation in 7 patients with primary immunodeficiency diseases treated at the National University Hospital, Singapore, over the period from December 1996 to January 2010. The primary immunodeficiency diseases managed were X-linked hyperimmunoglobulin M syndrome (n = 3), severe combined immunodeficiency (n = 1), leukocyte adhesion deficiency type 1 (n = 1), chronic granulomatous disease (n = 1), and Wiskott-Aldrich syndrome (n = 1). The age of the patients ranged from 5 months to 17 years. Conditioning regimen depended on the type of immunodeficiency, whereas supportive treatment was tailored for differing pretransplant conditions. Eight stem cell transplantations were performed for 7 patients. Donors were HLA-matched sibling donors for 2 patients and unrelated donors for the rest. At the median follow-up of 8.6 years (range 2.2-15.0 years) as of December 2011, 6 patients were alive and cured of their primary diseases. |
X Demographics
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Australia | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
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Portugal | 1 | 6% |
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