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Mendeley readers
| Title |
Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells
|
|---|---|
| Published in |
BMC Cancer, March 2012
|
| DOI | 10.1186/1471-2407-12-82 |
| Pubmed ID | |
| Authors |
Hannah Mak, Alexandra Naba, Sonal Varma, Colleen Schick, Andrew Day, Sandip K SenGupta, Monique Arpin, Bruce E Elliott |
| Abstract |
The membrane cytoskeletal crosslinker, ezrin, a member of the ERM family of proteins, is frequently over-expressed in human breast cancers, and is required for motility and invasion of epithelial cells. Our group previously showed that ezrin acts co-operatively with the non-receptor tyrosine kinase, Src, in deregulation of cell-cell contacts and scattering of epithelial cells. In particular, ezrin phosphorylation on Y477 by Src is specific to ezrin within the ERM family, and is required for HGF-induced scattering of epithelial cells. We therefore sought to examine the role of Y477 phosphorylation in ezrin on tumor progression. |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Australia | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 47 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 36% |
| Student > Master | 8 | 16% |
| Researcher | 6 | 12% |
| Professor > Associate Professor | 4 | 8% |
| Professor | 3 | 6% |
| Other | 7 | 14% |
| Unknown | 4 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 48% |
| Biochemistry, Genetics and Molecular Biology | 11 | 22% |
| Medicine and Dentistry | 5 | 10% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 5 | 10% |