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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles
|
|---|---|
| Published in |
Molecular Neurodegeneration, July 2019
|
| DOI | 10.1186/s13024-019-0329-1 |
| Pubmed ID | |
| Authors |
Richard M. Meade, David P. Fairlie, Jody M. Mason |
| Abstract |
Alpha-synuclein (αS) is the major constituent of Lewy bodies and a pathogenic hallmark of all synucleinopathathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). All diseases are determined by αS aggregate deposition but can be separated into distinct pathological phenotypes and diagnostic criteria. Here we attempt to reinterpret the literature, particularly in terms of how αS structure may relate to pathology. We do so in the context of a rapidly evolving field, taking into account newly revealed structural information on both native and pathogenic forms of the αS protein, including recent solid state NMR and cryoEM fibril structures. We discuss how these new findings impact on current understanding of αS and PD, and where this information may direct the field. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 9 | 47% |
| United States | 2 | 11% |
| Spain | 1 | 5% |
| Canada | 1 | 5% |
| Finland | 1 | 5% |
| Unknown | 5 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 11 | 58% |
| Members of the public | 7 | 37% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 527 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 527 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 93 | 18% |
| Researcher | 60 | 11% |
| Student > Bachelor | 59 | 11% |
| Student > Master | 54 | 10% |
| Student > Doctoral Student | 17 | 3% |
| Other | 49 | 9% |
| Unknown | 195 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 103 | 20% |
| Neuroscience | 69 | 13% |
| Chemistry | 37 | 7% |
| Agricultural and Biological Sciences | 26 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 24 | 5% |
| Other | 60 | 11% |
| Unknown | 208 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2024.
All research outputs
#1,039,082
of 26,017,215 outputs
Outputs from Molecular Neurodegeneration
#65
of 992 outputs
Outputs of similar age
#21,885
of 362,223 outputs
Outputs of similar age from Molecular Neurodegeneration
#4
of 16 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 992 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.8. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,223 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.