Title |
Disulfiram neuropathy: two case reports
|
---|---|
Published in |
Journal of Medical Case Reports, March 2016
|
DOI | 10.1186/s13256-016-0865-z |
Pubmed ID | |
Authors |
Anh Thu Tran, Richard A. Rison, Said R. Beydoun |
Abstract |
Neuropathy is a rare adverse side effect of disulfiram therapy and is under-recognized. There have been few case reports documenting this side effect. Two cases of disulfiram peripheral neuropathy are discussed. The first case is that of a 25-year-old Caucasian woman who was exposed to disulfiram therapy for a total of 8 months and developed pain and stiffness that prevented her from walking. The second case is that of a 46-year-old Caucasian woman who developed sudden-onset numbness in her lower extremities with progression to pain. Her symptoms improved over the course of 2 months after cessation of disulfiram therapy. In both cases, symptoms improved after cessation of disulfiram therapy. Disulfiram neuropathy occurs in persons with a history of chronic alcohol use. It is under-recognized and often attributed to alcoholic neuropathy given its comorbidity with alcoholic neuropathy. A greater understanding of this side effect may reduce neurologic complications related to disulfiram neuropathy and aid in early withdrawal of this offending agent. |
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Demographic breakdown
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Other | 3 | 14% |
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Researcher | 3 | 14% |
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Unknown | 3 | 14% |
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