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Mendeley readers
Attention Score in Context
| Title |
Definitive host influences the proteomic profile of excretory/secretory products of the trematode Echinostoma caproni
|
|---|---|
| Published in |
Parasites & Vectors, March 2016
|
| DOI | 10.1186/s13071-016-1465-x |
| Pubmed ID | |
| Authors |
Alba Cortés, Javier Sotillo, Carla Muñoz-Antolí, María Trelis, J. Guillermo Esteban, Rafael Toledo |
| Abstract |
Echinostoma caproni is an intestinal trematode extensively used as experimental model for the study of factors that determine the course of intestinal helminth infections, since this markedly depends on the host species. Although the host-dependent mechanisms for either chronic establishment or early parasite rejection have been broadly studied, little is known regarding the parasite response against different host environments. To identify host-dependent differentially expressed proteins, a comparative proteomic analysis of the excretory/secretory products released from E. caproni adults, isolated from hosts displaying different compatibility with this trematode, was performed. A total of 19 differential protein spots were identified (14 overexpressed in mice and 5 overexpressed in rats). The establishment of chronic infections in mice is mainly associated with the overexpression by adult worms of antioxidant and detoxifying enzymes (e.g. glutathione S-transferase, hydroxyacylglutathione hydrolase, thiopurine S-transferase, etc.) and metabolic enzymes like enolase, leucine aminopeptidase or malate dehydrogenase. However, the overexpression of cathepsin L and the structural protein actin observed in worms isolated from rats seems not to be effective for the colonization of the intestinal mucosa of this host. The observed differences suggest that protein expression and/or release is modulated by the local environment generated inside the host and provide useful insights in regards to the resistance mechanisms developed by parasites to ensure their long-term survival. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 19% |
| Student > Ph. D. Student | 5 | 16% |
| Student > Doctoral Student | 4 | 13% |
| Student > Master | 4 | 13% |
| Student > Bachelor | 3 | 10% |
| Other | 5 | 16% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 6 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 13% |
| Agricultural and Biological Sciences | 4 | 13% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Veterinary Science and Veterinary Medicine | 3 | 10% |
| Other | 6 | 19% |
| Unknown | 5 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2022.
All research outputs
#6,808,508
of 22,858,915 outputs
Outputs from Parasites & Vectors
#1,543
of 5,470 outputs
Outputs of similar age
#96,339
of 301,001 outputs
Outputs of similar age from Parasites & Vectors
#43
of 182 outputs
Altmetric has tracked 22,858,915 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 5,470 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,001 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 182 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.