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Mendeley readers
| Title |
Revealing the kinetics of Leishmania chagasi infection in the male genital system of hamsters
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|---|---|
| Published in |
Infectious Diseases of Poverty, March 2016
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| DOI | 10.1186/s40249-016-0122-0 |
| Pubmed ID | |
| Authors |
Amanda P. N. Quintal, Bruna C. Borges, Paula C. Brígido, Rebecca T. Silva, Ana F. Notário, Marlus A. Santos, Maria A. de Souza, Fernanda G. O. Nascimento, Antônio V. Mundim, Guilherme M. J. Costa, André B. Vasconcelos, Claudio V. da Silva |
| Abstract |
Leishmaniasis causes alterations and lesions in the genital system, which leads to azoospermia and testicular atrophy in animals during the chronic phase of the infection. The aim of this study was to reveal the kinetics of Leishmania chagasi infection in the genital system of male golden hamsters (Mesocricetus auratus). Animals were intraperitoneally inoculated with amastigotes from L. chagasi. At different time points animals were euthanized and genital organs processed for histo-pathological, qPCR, cytokines and testosterone detection assays. Our results showed a high parasite load in testis, followed by an increase of pro-inflammatory cytokines IL1-β, TNF-α and IFN-γ, and testosterone. Subsequently, IL-4 expression was upregulated and basal parasite persistence in testis was observed using the experimental approach. Extracellular amastigotes migrated to the epididymis posing as a potential major factor of parasite persistence and venereal transmission of L. chagasi infection in hamsters. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 5% |
| Unknown | 18 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 26% |
| Researcher | 4 | 21% |
| Student > Master | 3 | 16% |
| Student > Doctoral Student | 2 | 11% |
| Professor | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 1 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 26% |
| Agricultural and Biological Sciences | 4 | 21% |
| Immunology and Microbiology | 3 | 16% |
| Biochemistry, Genetics and Molecular Biology | 3 | 16% |
| Unknown | 4 | 21% |