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Syndrome of inappropriate antidiuretic hormone in a patient with leptomeningeal carcinomatosis

Overview of attention for article published in Journal of Medical Case Reports, March 2016
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Title
Syndrome of inappropriate antidiuretic hormone in a patient with leptomeningeal carcinomatosis
Published in
Journal of Medical Case Reports, March 2016
DOI 10.1186/s13256-016-0862-2
Pubmed ID
Authors

Roosevelt Boursiquot, Danielle Krol, Sameul Hanif, Javier Rojas, Maneesh Jain

Abstract

Leptomeningeal carcinomatosis is a condition in which metastatic cancer cells infiltrate the meninges of the brain and spinal cord, progressing to also involve the cerebrospinal fluid. Incidence of leptomeningeal carcinomatosis arising from an esophageal cancer is particularly rare. Here, we present a case report of a 76-year-old Caucasian man with a history of esophageal adenocarcinoma status-post chemoradiation followed by resection. He was admitted to our unit for intractable headache, nausea without emesis, anorexia, weakness, gait instability, delirium, syncope, and near syncope. Our diagnostic workup revealed leptomeningeal carcinomatosis and syndrome of inappropriate antidiuretic hormone. Our patient was treated with lumbar puncture for the headache, methotrexate for the leptomeningeal carcinomatosis, and table salt for the syndrome of inappropriate antidiuretic hormone. Despite our best efforts, our patient died 6 weeks posttreatment. Understanding the molecular pathogenesis of the development of syndrome of inappropriate antidiuretic hormone associated with leptomeningeal carcinomatosis from metastatic esophageal adenocarcinoma would help us to identify patients at risk and treat them accordingly.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 24%
Student > Master 3 7%
Student > Ph. D. Student 3 7%
Lecturer 2 5%
Student > Doctoral Student 2 5%
Other 7 17%
Unknown 14 34%
Readers by discipline Count As %
Medicine and Dentistry 15 37%
Nursing and Health Professions 7 17%
Biochemistry, Genetics and Molecular Biology 2 5%
Unspecified 1 2%
Environmental Science 1 2%
Other 1 2%
Unknown 14 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2016.
All research outputs
#18,449,393
of 22,858,915 outputs
Outputs from Journal of Medical Case Reports
#2,262
of 3,924 outputs
Outputs of similar age
#220,314
of 301,001 outputs
Outputs of similar age from Journal of Medical Case Reports
#30
of 48 outputs
Altmetric has tracked 22,858,915 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,924 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,001 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.