Title |
β-Glucan exacerbates allergic airway responses to house dust mite allergen
|
---|---|
Published in |
Respiratory Research, April 2016
|
DOI | 10.1186/s12931-016-0352-5 |
Pubmed ID | |
Authors |
Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I. Murray, David L. Williams, Bart N. Lambrecht, Frank Brombacher, Gordon D. Brown |
Abstract |
β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 40% |
Belgium | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 20% |
Student > Ph. D. Student | 7 | 17% |
Student > Master | 6 | 15% |
Student > Bachelor | 4 | 10% |
Lecturer | 2 | 5% |
Other | 3 | 7% |
Unknown | 11 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 9 | 22% |
Agricultural and Biological Sciences | 7 | 17% |
Medicine and Dentistry | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Other | 3 | 7% |
Unknown | 12 | 29% |