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Production of medium-chain fatty acids and higher alcohols by a synthetic co-culture grown on carbon monoxide or syngas

Overview of attention for article published in Biotechnology for Biofuels, April 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

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13 tweeters
patent
3 patents

Citations

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140 Dimensions

Readers on

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251 Mendeley
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Title
Production of medium-chain fatty acids and higher alcohols by a synthetic co-culture grown on carbon monoxide or syngas
Published in
Biotechnology for Biofuels, April 2016
DOI 10.1186/s13068-016-0495-0
Pubmed ID
Authors

Martijn Diender, Alfons J. M. Stams, Diana Z. Sousa

Abstract

Synthesis gas, a mixture of CO, H2, and CO2, is a promising renewable feedstock for bio-based production of organic chemicals. Production of medium-chain fatty acids can be performed via chain elongation, utilizing acetate and ethanol as main substrates. Acetate and ethanol are main products of syngas fermentation by acetogens. Therefore, syngas can be indirectly used as a substrate for the chain elongation process. Here, we report the establishment of a synthetic co-culture consisting of Clostridium autoethanogenum and Clostridium kluyveri. Together, these bacteria are capable of converting CO and syngas to a mixture of C4 and C6 fatty acids and their respective alcohols. The co-culture is able to grow using solely CO or syngas as a substrate, and presence of acetate significantly stimulated production rates. The co-culture produced butyrate and caproate at a rate of 8.5 ± 1.1 and 2.5 ± 0.63 mmol/l/day, respectively. Butanol and hexanol were produced at a rate of 3.5 ± 0.69 and 2.0 ± 0.46 mmol/l/day, respectively. The pH was found to be a major factor during cultivation, influencing the growth performance of the separate strains and caproate toxicity. This co-culture poses an alternative way to produce medium-chain fatty acids and higher alcohols from carbon monoxide or syngas and the process can be regarded as an integration of syngas fermentation and chain elongation in one growth vessel.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 251 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
New Zealand 1 <1%
United States 1 <1%
Unknown 248 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 57 23%
Researcher 44 18%
Student > Master 36 14%
Student > Bachelor 25 10%
Student > Doctoral Student 15 6%
Other 28 11%
Unknown 46 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 48 19%
Agricultural and Biological Sciences 33 13%
Environmental Science 29 12%
Engineering 26 10%
Chemical Engineering 23 9%
Other 28 11%
Unknown 64 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2019.
All research outputs
#2,583,672
of 20,987,357 outputs
Outputs from Biotechnology for Biofuels
#142
of 1,378 outputs
Outputs of similar age
#44,736
of 279,243 outputs
Outputs of similar age from Biotechnology for Biofuels
#2
of 4 outputs
Altmetric has tracked 20,987,357 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,378 research outputs from this source. They receive a mean Attention Score of 4.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,243 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.