Title |
Experimental neurotransplantation treatment for hereditary cerebellar ataxias
|
---|---|
Published in |
Cerebellum & Ataxias, April 2016
|
DOI | 10.1186/s40673-016-0045-3 |
Pubmed ID | |
Authors |
Jan Cendelin |
Abstract |
Hereditary cerebellar degenerations are a heterogeneous group of diseases often having a detrimental impact on patients' quality of life. Unfortunately, no sufficiently effective causal therapy is available for human patients at present. There are several therapies that have been shown to affect the pathogenetic process and thereby to delay the progress of the disease in mouse models of cerebellar ataxias. The second experimental therapeutic approach for hereditary cerebellar ataxias is neurotransplantation. Grafted cells might provide an effect via delivery of a scarce neurotransmitter, substitution of lost cells if functionally integrated and rescue or trophic support of degenerating cells. The results of cerebellar transplantation research over the past 30 years are reviewed here and potential benefits and limitations of neurotransplantation therapy are discussed. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 18% |
Researcher | 3 | 18% |
Lecturer | 2 | 12% |
Professor > Associate Professor | 2 | 12% |
Student > Master | 2 | 12% |
Other | 3 | 18% |
Unknown | 2 | 12% |
Readers by discipline | Count | As % |
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Neuroscience | 3 | 18% |
Agricultural and Biological Sciences | 3 | 18% |
Engineering | 2 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 2 | 12% |
Unknown | 4 | 24% |