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Combined effects of salicylic acid and furosemide and noise on hearing

Overview of attention for article published in Journal of Occupational Medicine and Toxicology, January 2012
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Title
Combined effects of salicylic acid and furosemide and noise on hearing
Published in
Journal of Occupational Medicine and Toxicology, January 2012
DOI 10.1186/1745-6673-7-1
Pubmed ID
Authors

Marrigje A de Jong, Cahtia Adelman, Melissa Rubin, Haim Sohmer

Abstract

A major cause of the hearing loss following exposure to intense noise involves release of free radicals resulting from the elevated metabolism. The free radicals induce damage to several of the components of the cochlear amplifier including the outer hair cells and indirectly to the transduction currents. Salicylic acid induces a reversible hearing loss since it binds to the motor protein prestin in the outer hair cells, reducing electromotility. Furosemide also induces a reversible hearing loss since it reduces the endocochlear potential which is a major component of the cochlear transduction currents. On the other hand, each of these drugs also provides protection from a noise induced hearing loss if they are injected just before a noise exposure, probably as a result of the decreased metabolism induced in their presence, with release of lower levels of free radicals. In this study, both drugs were administered in order to assess whether their protective effects would be additive.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Other 3 14%
Student > Ph. D. Student 3 14%
Professor > Associate Professor 3 14%
Student > Master 3 14%
Other 2 10%
Unknown 3 14%
Readers by discipline Count As %
Medicine and Dentistry 6 29%
Agricultural and Biological Sciences 5 24%
Engineering 3 14%
Psychology 1 5%
Nursing and Health Professions 1 5%
Other 0 0%
Unknown 5 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2014.
All research outputs
#14,964,928
of 23,935,525 outputs
Outputs from Journal of Occupational Medicine and Toxicology
#194
of 404 outputs
Outputs of similar age
#158,634
of 251,391 outputs
Outputs of similar age from Journal of Occupational Medicine and Toxicology
#13
of 17 outputs
Altmetric has tracked 23,935,525 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 404 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,391 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.