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Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients

Overview of attention for article published in Lipids in Health and Disease, March 2012
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Title
Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients
Published in
Lipids in Health and Disease, March 2012
DOI 10.1186/1476-511x-11-39
Pubmed ID
Authors

Antonella Mandas, Claudia Abete, Paolo Francesco Putzu, Paolo la Colla, Sandra Dessì, Alessandra Pani

Abstract

Cholesterol homeostasis dysfunction has been reported to have role in the pathogenesis of Alzheimer disease (AD). Therefore, changes in cholesterol metabolism in blood components may help to develop new potential AD biomarkers. In this study changes in cholesterol metabolism-related gene expression genes were evaluated in peripheral blood mononuclear cells (PBMCs) from AD subjects, their first degree relatives (FDR) and two groups of age matched controls (C1 > 80 years, C2 < 60 years). The expression of three genes related to APP processing was also determined.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Argentina 1 3%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 21%
Researcher 7 18%
Student > Postgraduate 4 10%
Student > Master 4 10%
Student > Doctoral Student 3 8%
Other 7 18%
Unknown 6 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 31%
Medicine and Dentistry 4 10%
Chemistry 4 10%
Biochemistry, Genetics and Molecular Biology 3 8%
Neuroscience 3 8%
Other 5 13%
Unknown 8 21%