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Dysregulation of over-expressed IL-32 in colorectal cancer induces metastasis

Overview of attention for article published in World Journal of Surgical Oncology, April 2015
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Title
Dysregulation of over-expressed IL-32 in colorectal cancer induces metastasis
Published in
World Journal of Surgical Oncology, April 2015
DOI 10.1186/s12957-015-0552-3
Pubmed ID
Authors

Yi Yang, Zihao Wang, Yiming Zhou, Xiaoxiao Wang, Jianbin Xiang, Zongyou Chen

Abstract

Interleukin (IL)-32 is a described intracellular pluripotent pro-inflammatory mediator, characterized by the signaling of NF-κB and STAT3. Our study investigated whether IL-32 expression has clinical significance in the metastases of colorectal cancer (CRC). A total of 70 CRC patients were enrolled, 47 cases of which were single CRC organic metastasis lesions while the rest of which were primary CRC lesions (T4NxM0). IL-32 expression was detected by immunohistochemistry, and the correlation between IL-32 expression and CRC metastases was analyzed. The positive rates of IL-32 in the CRC organic metastasis group were more severe than those in the primary CRC group (P < 0.05). The positive rate of IL-32 in primary CRC with lymph node metastasis was more severe than that of IL-32 in primary CRC without lymph node metastasis (P < 0.05). The level of IL-32 expression could influence the N grade of CRC. Thus, IL-32 expression may stimulate the organic metastasis and the lymph node metastasis of CRC.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 24%
Student > Master 3 18%
Student > Bachelor 1 6%
Other 1 6%
Researcher 1 6%
Other 1 6%
Unknown 6 35%
Readers by discipline Count As %
Medicine and Dentistry 5 29%
Biochemistry, Genetics and Molecular Biology 3 18%
Agricultural and Biological Sciences 1 6%
Nursing and Health Professions 1 6%
Unknown 7 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2016.
All research outputs
#17,796,099
of 22,860,626 outputs
Outputs from World Journal of Surgical Oncology
#869
of 2,045 outputs
Outputs of similar age
#180,697
of 264,621 outputs
Outputs of similar age from World Journal of Surgical Oncology
#25
of 65 outputs
Altmetric has tracked 22,860,626 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,045 research outputs from this source. They receive a mean Attention Score of 2.1. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,621 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.