Title |
Phylogenetic comparison of exonic US4, US7 and UL44 regions of clinical herpes simplex virus type 1 isolates showed lack of association between their anatomic sites of infection and genotypic/sub genotypic classification
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Published in |
Virology Journal, March 2012
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DOI | 10.1186/1743-422x-9-65 |
Pubmed ID | |
Authors |
Anusha Harishankar, Malathi Jambulingam, Raajaram Gowrishankar, Annapoorni Venkatachalam, Umashankar Vetrivel, Sathyabaarathi Ravichandran, Samson Moses Yesupadam, Hajib Narahari Rao Madhavan |
Abstract |
HSV-1 genome is a mosaic of recombinants. Clinical Herpes simplex virus -1 (HSV1) isolates were already genotyped as A, B and C types based on nucleotide variations at Unique Short (US) 4 (gG) and US 7 (gI) regions through phylogeny. Analysis of Glycoprotein C (gC) exon present on the Unique Long (UL) region had also revealed the existence of different genotypes. Glycoprotein C is mainly involved in initial viral attachment to heparan sulphate on host cell surface facilitating the virus's binding and penetration into cell. As the amount of heparan sulphate on the host cell surface varies according to the cell type, it is plausible that different genotypes bind differentially to cell types. Hence, this study was framed to determine the existence of novel genotypes/sub genotypes in the US or UL regions which could associate with clinical entities. |
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United States | 1 | 100% |
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Members of the public | 1 | 100% |
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