Title |
A low protein diet during pregnancy provokes a lasting shift of hepatic expression of genes related to cell cycle throughout ontogenesis in a porcine model
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Published in |
BMC Genomics, March 2012
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DOI | 10.1186/1471-2164-13-93 |
Pubmed ID | |
Authors |
Michael Oster, Eduard Murani, Cornelia C Metges, Siriluck Ponsuksili, Klaus Wimmers |
Abstract |
In rodent models and in humans the impact of gestational diets on the offspring's phenotype was shown experimentally and epidemiologically. Adverse environmental conditions during fetal development provoke an intrauterine adaptive response termed 'fetal programming', which may lead to both persistently biased responsiveness to extrinsic factors and permanent consequences for the organismal phenotype. This leads to the hypothesis that the offspring's transcriptome exhibits short-term and long-term changes, depending on the maternal diet. In order to contribute to a comprehensive inventory of genes and functional networks that are targets of nutritional programming initiated during fetal life, we applied whole-genome microarrays for expression profiling in a longitudinal experimental design covering prenatal, perinatal, juvenile, and adult ontogenetic stages in a porcine model. Pregnant sows were fed either a gestational low protein diet (LP, 6% CP) or an adequate protein diet (AP, 12% CP). All offspring was nursed by foster sows receiving standard diets. After weaning, all offspring was fed standard diets ad libitum. |
X Demographics
Geographical breakdown
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United States | 3 | 23% |
India | 2 | 15% |
Unknown | 8 | 62% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 12 | 92% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
United States | 1 | 3% |
India | 1 | 3% |
Unknown | 37 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 28% |
Student > Postgraduate | 4 | 10% |
Student > Doctoral Student | 4 | 10% |
Researcher | 3 | 8% |
Student > Master | 3 | 8% |
Other | 5 | 13% |
Unknown | 10 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 13% |
Immunology and Microbiology | 3 | 8% |
Nursing and Health Professions | 2 | 5% |
Environmental Science | 1 | 3% |
Other | 7 | 18% |
Unknown | 11 | 28% |