↓ Skip to main content

MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets

Overview of attention for article published in Genome Biology, March 2012
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
2 blogs
twitter
11 X users
patent
1 patent
peer_reviews
1 peer review site
wikipedia
1 Wikipedia page

Citations

dimensions_citation
352 Dimensions

Readers on

mendeley
480 Mendeley
citeulike
10 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets
Published in
Genome Biology, March 2012
DOI 10.1186/gb-2012-13-3-r16
Pubmed ID
Authors

Zhen Shao, Yijing Zhang, Guo-Cheng Yuan, Stuart H Orkin, David J Waxman

Abstract

ChIP-Seq is widely used to characterize genome-wide binding patterns of transcription factors and other chromatin-associated proteins. Although comparison of ChIP-Seq data sets is critical for understanding cell type-dependent and cell state-specific binding, and thus the study of cell-specific gene regulation, few quantitative approaches have been developed. Here, we present a simple and effective method, MAnorm, for quantitative comparison of ChIP-Seq data sets describing transcription factor binding sites and epigenetic modifications. The quantitative binding differences inferred by MAnorm showed strong correlation with both the changes in expression of target genes and the binding of cell type-specific regulators.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 480 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 12 3%
United Kingdom 6 1%
France 3 <1%
Italy 3 <1%
China 3 <1%
Germany 3 <1%
Japan 2 <1%
Sweden 1 <1%
Australia 1 <1%
Other 11 2%
Unknown 435 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 154 32%
Student > Ph. D. Student 116 24%
Student > Master 48 10%
Professor > Associate Professor 26 5%
Student > Bachelor 20 4%
Other 64 13%
Unknown 52 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 242 50%
Biochemistry, Genetics and Molecular Biology 99 21%
Computer Science 21 4%
Immunology and Microbiology 10 2%
Engineering 10 2%
Other 36 8%
Unknown 62 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2023.
All research outputs
#1,320,080
of 25,374,647 outputs
Outputs from Genome Biology
#1,028
of 4,467 outputs
Outputs of similar age
#6,825
of 170,511 outputs
Outputs of similar age from Genome Biology
#9
of 46 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,511 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.