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The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels

Overview of attention for article published in Molecular Brain, March 2012
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Title
The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels
Published in
Molecular Brain, March 2012
DOI 10.1186/1756-6606-5-9
Pubmed ID
Authors

Brett A Simms, Gerald W Zamponi

Abstract

A loss of function of the L-type calcium channel, Cav1.2, results in a cardiac specific disease known as Brugada syndrome. Although many Brugada syndrome channelopathies reduce channel function, one point mutation in the N-terminus of Cav1.2 (A39V) has been shown to elicit disease a phenotype because of a loss of surface trafficking of the channel. This lack of cell membrane expression could not be rescued by the trafficking chaperone Cavβ.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Switzerland 1 2%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 24%
Professor > Associate Professor 8 17%
Student > Ph. D. Student 6 13%
Professor 5 11%
Student > Master 5 11%
Other 7 15%
Unknown 4 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 22%
Neuroscience 9 20%
Medicine and Dentistry 8 17%
Biochemistry, Genetics and Molecular Biology 7 15%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Other 3 7%
Unknown 6 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2012.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Molecular Brain
#924
of 1,198 outputs
Outputs of similar age
#132,132
of 168,389 outputs
Outputs of similar age from Molecular Brain
#7
of 8 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,198 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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