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En1 and Wnt signaling in midbrain dopaminergic neuronal development

Overview of attention for article published in Neural Development, May 2011
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Title
En1 and Wnt signaling in midbrain dopaminergic neuronal development
Published in
Neural Development, May 2011
DOI 10.1186/1749-8104-6-23
Pubmed ID
Authors

Maria TM Alves dos Santos, Maria TM Alves dos Santos, Marten P Smidt

Abstract

Dopaminergic neurons of the ventral mesodiencephalon are affected in significant health disorders such as Parkinson's disease, schizophrenia, and addiction. The ultimate goal of current research endeavors is to improve the clinical treatment of such disorders, such as providing a protocol for cell replacement therapy in Parkinson's disease that will successfully promote the specific differentiation of a stem cell into a dopaminergic neuronal phenotype. Decades of research on the developmental mechanisms of the mesodiencephalic dopaminergic (mdDA) system have led to the identification of many signaling pathways and transcription factors critical in its development. The unraveling of these pathways will help fill in the pieces of the puzzle that today dominates neurodevelopment research: how to make and maintain a mdDA neuron. In the present review, we provide an overview of the mdDA system, the processes and signaling molecules involved in its genesis, with a focus on the transcription factor En1 and the canonical Wnt pathway, highlighting recent findings on their relevance--and interplay--in the development and maintenance of the mdDA system.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Netherlands 1 <1%
Austria 1 <1%
Portugal 1 <1%
Russia 1 <1%
Australia 1 <1%
Japan 1 <1%
Poland 1 <1%
Unknown 171 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 26%
Researcher 33 18%
Student > Master 23 13%
Student > Bachelor 22 12%
Student > Doctoral Student 11 6%
Other 20 11%
Unknown 24 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 74 41%
Biochemistry, Genetics and Molecular Biology 23 13%
Neuroscience 21 12%
Medicine and Dentistry 16 9%
Psychology 5 3%
Other 12 7%
Unknown 29 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2012.
All research outputs
#2,016,321
of 3,620,974 outputs
Outputs from Neural Development
#59
of 103 outputs
Outputs of similar age
#31,518
of 73,387 outputs
Outputs of similar age from Neural Development
#2
of 6 outputs
Altmetric has tracked 3,620,974 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
So far Altmetric has tracked 103 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 73,387 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.