Title |
The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ
|
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Published in |
Translational Neurodegeneration, April 2016
|
DOI | 10.1186/s40035-016-0054-4 |
Pubmed ID | |
Authors |
Cong Zheng, Xin-Wen Zhou, Jian-Zhi Wang |
Abstract |
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders in the elderly. Although the mechanisms underlying AD neurodegeneration are not fully understood, it is well recognized that inflammation plays a crucial role in the initiation and/or deterioration of AD neurodegeneration. Increasing evidence suggests that different cytokines, including interleukins, TNF-α, TGF-β and IFN-γ, are actively participated in AD pathogenesis and may serve as diagnostic or therapeutic targets for AD neurodegeneration. Here, we review the progress in understanding the important role that these cytokines or neuroinflammation has played in AD etiology and pathogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Portugal | 1 | <1% |
Unknown | 378 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 70 | 18% |
Student > Bachelor | 60 | 16% |
Student > Master | 59 | 16% |
Researcher | 32 | 8% |
Student > Doctoral Student | 19 | 5% |
Other | 50 | 13% |
Unknown | 90 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 67 | 18% |
Biochemistry, Genetics and Molecular Biology | 53 | 14% |
Agricultural and Biological Sciences | 46 | 12% |
Medicine and Dentistry | 35 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 21 | 6% |
Other | 51 | 13% |
Unknown | 107 | 28% |