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Pre-diagnosis blood glucose and prognosis in women with breast cancer

Overview of attention for article published in Cancer & Metabolism, April 2016
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Average Attention Score compared to outputs of the same age and source

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37 Mendeley
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Title
Pre-diagnosis blood glucose and prognosis in women with breast cancer
Published in
Cancer & Metabolism, April 2016
DOI 10.1186/s40170-016-0147-7
Pubmed ID
Authors

Behjatolah Monzavi-Karbassi, Rhonda Gentry, Varinder Kaur, Eric R. Siegel, Fariba Jousheghany, Srikanth Medarametla, Barbara J. Fuhrman, A. Mazin Safar, Laura F. Hutchins, Thomas Kieber-Emmons

Abstract

The effect of moderately elevated blood glucose levels among non-diabetic subjects on cancer prognosis is not well described. The goal of this study was to examine the association of elevated random blood glucose (RBG) levels in non-diabetic breast cancer patients with overall survival (OS) and time to tumor recurrence (TTR). Forty-nine deaths and 32 recurrences occurred among 148 eligible study subjects during 855.44 person-years of follow-up, with median follow-up of 5.97 years. We observed that patients with elevated RBG levels experienced significantly shorter OS (hazard ratio [HR], 3.01; 95 % confidence interval [CI] (1.70-5.33); P < 0.001) and shorter TTR (HR, 2.08; CI (1.04-4.16); P = 0.04) as compared to patients with non-elevated RBG levels. After controlling for tumor grade, tumor stage, race, and BMI, elevated RBG continued to display high and statistically significant association with shorter OS (HR, 3.50; CI (1.87-6.54); P < 0.001). Adjustment for age, race, and BMI strengthened HR of RBG for TTR. The association of RGB with TTR lost its borderline statistical significance upon controlling for both tumor grade and stage. The data suggest that elevated blood glucose is associated with poor prognosis of breast cancer patients. Given the potential clinical implication, these findings warrant further investigation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 24%
Student > Master 5 14%
Student > Bachelor 4 11%
Student > Ph. D. Student 3 8%
Student > Postgraduate 3 8%
Other 7 19%
Unknown 6 16%
Readers by discipline Count As %
Medicine and Dentistry 13 35%
Pharmacology, Toxicology and Pharmaceutical Science 4 11%
Biochemistry, Genetics and Molecular Biology 2 5%
Chemistry 2 5%
Nursing and Health Professions 1 3%
Other 5 14%
Unknown 10 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2019.
All research outputs
#13,647,287
of 23,870,022 outputs
Outputs from Cancer & Metabolism
#100
of 211 outputs
Outputs of similar age
#142,196
of 304,433 outputs
Outputs of similar age from Cancer & Metabolism
#4
of 6 outputs
Altmetric has tracked 23,870,022 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 211 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,433 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.