Title |
The Effect of Transdermal Delivery of Fentanyl on Activity in Growing Pigs
|
---|---|
Published in |
Acta Veterinaria Scandinavica, September 2005
|
DOI | 10.1186/1751-0147-46-149 |
Pubmed ID | |
Authors |
LM Malavasi, H Augustsson, M Jensen-Waern, G Nyman |
Abstract |
Recently, decreased activity levels have been observed in pigs treated postoperatively with transdermal delivery of fentanyl (TD-fentanyl) after isoflurane anaesthesia. Whether the change in behaviour is related to opioid-induced sedation or to insufficient pain relief remains to be investigated. This study was therefore undertaken to evaluate the effect of TD-fentanyl 50 microg h(-1) on the activity level with and without isoflurane anaesthesia. Eight pigs (25.4 +/- 5.2 kg) were submitted to a cross-over study and given two treatments; 1) fentanyl patch applied after 30 minutes of anaesthesia (treatment A/F) and 2) fentanyl patch without anaesthesia (treatment F). The pigs' behaviour was observed from a video recording instantaneously every 10 minutes for 24 h before treatments and up to 72 h after the patch attachment. Venous blood samples were taken 1, 6, 12, 24, 48 and 72 h after the patch application. The behaviour recordings showed that TD-fentanyl did not produce sedation in any pig. No differences were found between the two treatments in activity level, weight gain or serum fentanyl concentration. This concentration measured after 24 h was 0.27 +/- 0.11 ng ml(-1) and 0.47 +/- 0.40 ng ml(-1) in the A/F and F group, respectively. In conclusion, transdermal delivery of 50 microg h(-1) fentanyl did not cause inactivity in growing pigs. However, the large variations in serum fentanyl concentration indicate that drug absorption from transdermal patches is unpredictable and sometimes deficient. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 25% |
Researcher | 4 | 17% |
Other | 3 | 13% |
Student > Master | 2 | 8% |
Librarian | 1 | 4% |
Other | 4 | 17% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 7 | 29% |
Medicine and Dentistry | 7 | 29% |
Agricultural and Biological Sciences | 2 | 8% |
Psychology | 1 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Other | 2 | 8% |
Unknown | 4 | 17% |