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Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis

Overview of attention for article published in BMC Immunology, March 2012
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4 X users

Citations

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45 Dimensions

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74 Mendeley
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1 CiteULike
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Title
Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis
Published in
BMC Immunology, March 2012
DOI 10.1186/1471-2172-13-13
Pubmed ID
Authors

Sathi Babu Chodisetti, Pradeep K Rai, Uthaman Gowthaman, Susanta Pahari, Javed N Agrewala

Abstract

Molecular mimicry between microbial antigens and host-proteins is one of the etiological enigmas for the occurrence of autoimmune diseases. T cells that recognize cross-reactive epitopes may trigger autoimmune reactions. Intriguingly, autoimmune diseases have been reported to be prevalent in tuberculosis endemic populations. Further, association of Mycobacterium tuberculosis (M. tuberculosis) has been implicated in different autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. Although, in silico analyses have identified a number of M. tuberculosis specific vaccine candidates, the analysis on prospective cross-reactive epitopes, that may elicit autoimmune response, has not been yet attempted. Here, we have employed bioinformatics tools to determine T cell epitopes of homologous antigenic regions between M. tuberculosis and human proteomes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ireland 1 1%
Germany 1 1%
South Africa 1 1%
Unknown 71 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 22%
Researcher 13 18%
Student > Master 12 16%
Student > Bachelor 6 8%
Student > Doctoral Student 4 5%
Other 14 19%
Unknown 9 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 30%
Immunology and Microbiology 16 22%
Medicine and Dentistry 15 20%
Biochemistry, Genetics and Molecular Biology 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 3 4%
Unknown 10 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2015.
All research outputs
#14,725,323
of 22,663,969 outputs
Outputs from BMC Immunology
#287
of 588 outputs
Outputs of similar age
#99,463
of 160,638 outputs
Outputs of similar age from BMC Immunology
#6
of 12 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 588 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,638 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.