Title |
Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis
|
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Published in |
BMC Immunology, March 2012
|
DOI | 10.1186/1471-2172-13-13 |
Pubmed ID | |
Authors |
Sathi Babu Chodisetti, Pradeep K Rai, Uthaman Gowthaman, Susanta Pahari, Javed N Agrewala |
Abstract |
Molecular mimicry between microbial antigens and host-proteins is one of the etiological enigmas for the occurrence of autoimmune diseases. T cells that recognize cross-reactive epitopes may trigger autoimmune reactions. Intriguingly, autoimmune diseases have been reported to be prevalent in tuberculosis endemic populations. Further, association of Mycobacterium tuberculosis (M. tuberculosis) has been implicated in different autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. Although, in silico analyses have identified a number of M. tuberculosis specific vaccine candidates, the analysis on prospective cross-reactive epitopes, that may elicit autoimmune response, has not been yet attempted. Here, we have employed bioinformatics tools to determine T cell epitopes of homologous antigenic regions between M. tuberculosis and human proteomes. |
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United States | 1 | 25% |
Unknown | 2 | 50% |
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Mendeley readers
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Researcher | 13 | 18% |
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