Title |
Timing and source of subtype-C HIV-1 superinfection in the newly infected partner of Zambian couples with disparate viruses
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Published in |
Retrovirology, March 2012
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DOI | 10.1186/1742-4690-9-22 |
Pubmed ID | |
Authors |
Colleen S Kraft, Debby Basu, Paulina A Hawkins, Peter T Hraber, Elwyn Chomba, Joseph Mulenga, William Kilembe, Naw H Khu, Cynthia A Derdeyn, Susan A Allen, Olivier Manigart, Eric Hunter |
Abstract |
HIV-1 superinfection occurs at varying frequencies in different at risk populations. Though seroincidence is decreased, in the negative partner of HIV-discordant couples after joint testing and counseling in the Zambia Emory HIV Research Project (ZEHRP) cohort, the annual infection rate remains relatively high at 7-8%. Based on sequencing within the gp41 region of each partner's virus, 24% of new infections between 2004 and 2008 were the result of transmission from a non-spousal partner. Since these seroconvertors and their spouses have disparate epidemiologically-unlinked viruses, there is a risk of superinfection within the marriage. We have, therefore, investigated the incidence and viral origin of superinfection in these couples. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Unknown | 37 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 24% |
Student > Ph. D. Student | 7 | 18% |
Student > Master | 6 | 16% |
Student > Bachelor | 4 | 11% |
Professor | 4 | 11% |
Other | 5 | 13% |
Unknown | 3 | 8% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 26% |
Agricultural and Biological Sciences | 7 | 18% |
Immunology and Microbiology | 4 | 11% |
Social Sciences | 3 | 8% |
Economics, Econometrics and Finance | 2 | 5% |
Other | 4 | 11% |
Unknown | 8 | 21% |