Title |
Dermal fibroblasts display similar phenotypic and differentiation capacity to fat-derived mesenchymal stem cells, but differ in anti-inflammatory and angiogenic potential
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Published in |
Vascular Cell, February 2011
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DOI | 10.1186/2045-824x-3-5 |
Pubmed ID | |
Authors |
Antonella Blasi, Carmela Martino, Luigi Balducci, Marilisa Saldarelli, Antonio Soleti, Stefania E Navone, Laura Canzi, Silvia Cristini, Gloria Invernici, Eugenio A Parati, Giulio Alessandri |
Abstract |
Mesenchymal stem cells (MSCs) are multipotent stem cells able to differentiate into different cell lineages. However, MSCs represent a subpopulation of a more complex cell composition of stroma cells contained in mesenchymal tissue. Due to a lack of specific markers, it is difficult to distinguish MSCs from other more mature stromal cells such as fibroblasts, which, conversely, are abundant in mesenchymal tissue. In order to find more distinguishing features between MSCs and fibroblasts, we studied the phenotypic and functional features of human adipose-derived MSCs (AD-MSCs) side by side with normal human dermal fibroblasts (HNDFs) in vitro |
X Demographics
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 4 | 3% |
Brazil | 1 | <1% |
Finland | 1 | <1% |
France | 1 | <1% |
New Zealand | 1 | <1% |
United Kingdom | 1 | <1% |
Japan | 1 | <1% |
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Unknown | 137 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 36 | 24% |
Student > Ph. D. Student | 26 | 18% |
Student > Bachelor | 18 | 12% |
Student > Master | 13 | 9% |
Student > Doctoral Student | 8 | 5% |
Other | 15 | 10% |
Unknown | 32 | 22% |
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Biochemistry, Genetics and Molecular Biology | 25 | 17% |
Medicine and Dentistry | 18 | 12% |
Immunology and Microbiology | 6 | 4% |
Computer Science | 3 | 2% |
Other | 13 | 9% |
Unknown | 37 | 25% |