Title |
Angiogenic potential of endothelial progenitor cells and embryonic stem cells
|
---|---|
Published in |
Vascular Cell, May 2011
|
DOI | 10.1186/2045-824x-3-11 |
Pubmed ID | |
Authors |
Peter C Rae, Richard DW Kelly, Stuart Egginton, Justin C St John |
Abstract |
Endothelial progenitor cells (EPCs) are implicated in a range of pathological conditions, suggesting a natural therapeutic role for EPCs in angiogenesis. However, current angiogenic therapies involving EPC transplantation are inefficient due to rejection of donor EPCs. One solution is to derive an expanded population of EPCs from stem cells in vitro, to be re-introduced as a therapeutic transplant. To demonstrate the therapeutic potential of EPCs we performed in vitro transplantation of EPCs into endothelial cell (EC) tubules using a gel-based tubule formation assay. We also described the production of highly angiogenic EPC-comparable cells from pluripotent embryonic stem cells (ESCs) by direct differentiation using EC-conditioned medium (ECCM). |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Indonesia | 1 | 2% |
Iran, Islamic Republic of | 1 | 2% |
France | 1 | 2% |
Germany | 1 | 2% |
Unknown | 46 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 22% |
Student > Ph. D. Student | 10 | 20% |
Student > Master | 8 | 16% |
Student > Doctoral Student | 6 | 12% |
Student > Bachelor | 3 | 6% |
Other | 10 | 20% |
Unknown | 2 | 4% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 28% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Engineering | 3 | 6% |
Immunology and Microbiology | 2 | 4% |
Other | 4 | 8% |
Unknown | 2 | 4% |