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Acetylcholinesterase inhibition ameliorates deficits in motivational drive

Overview of attention for article published in Behavioral and Brain Functions, March 2012
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Title
Acetylcholinesterase inhibition ameliorates deficits in motivational drive
Published in
Behavioral and Brain Functions, March 2012
DOI 10.1186/1744-9081-8-15
Pubmed ID
Authors

Keri Martinowich, Kathleen M Cardinale, Robert J Schloesser, Michael Hsu, Nigel H Greig, Husseini K Manji

Abstract

Apathy is frequently observed in numerous neurological disorders, including Alzheimer's and Parkinson's, as well as neuropsychiatric disorders including schizophrenia. Apathy is defined as a lack of motivation characterized by diminished goal-oriented behavior and self-initiated activity. This study evaluated a chronic restraint stress (CRS) protocol in modeling apathetic behavior, and determined whether administration of an anticholinesterase had utility in attenuating CRS-induced phenotypes.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 75 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 17%
Student > Bachelor 13 17%
Student > Ph. D. Student 12 16%
Student > Master 10 13%
Student > Doctoral Student 5 7%
Other 11 14%
Unknown 12 16%
Readers by discipline Count As %
Medicine and Dentistry 17 22%
Neuroscience 10 13%
Psychology 10 13%
Agricultural and Biological Sciences 5 7%
Sports and Recreations 5 7%
Other 13 17%
Unknown 16 21%