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Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance

Overview of attention for article published in BMC Cancer, March 2012
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Title
Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance
Published in
BMC Cancer, March 2012
DOI 10.1186/1471-2407-12-109
Pubmed ID
Authors

Michael Heise, Anja Lautem, Johanna Knapstein, Jörn M Schattenberg, Maria Hoppe-Lotichius, Daniel Foltys, Nina Weiler, Anca Zimmermann, Arno Schad, Dirk Gründemann, Gerd Otto, Peter R Galle, Marcus Schuchmann, Tim Zimmermann

Abstract

Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates and detoxification of xenobiotics and chemotherapeutics. The transporters became pharmaceutically interesting, because OCTs are determinants of the cytotoxicity of platin derivates and the transport activity has been shown to correlate with the sensitivity of tumors towards tyrosine kinase inhibitors. No data exist about the relevance of OCTs in hepatocellular carcinoma (HCC).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
France 1 2%
Germany 1 2%
Unknown 47 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 36%
Student > Ph. D. Student 8 16%
Student > Master 4 8%
Student > Doctoral Student 3 6%
Professor > Associate Professor 3 6%
Other 8 16%
Unknown 6 12%
Readers by discipline Count As %
Medicine and Dentistry 13 26%
Biochemistry, Genetics and Molecular Biology 9 18%
Agricultural and Biological Sciences 7 14%
Pharmacology, Toxicology and Pharmaceutical Science 7 14%
Chemistry 2 4%
Other 5 10%
Unknown 7 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2012.
All research outputs
#20,156,138
of 22,663,969 outputs
Outputs from BMC Cancer
#6,480
of 8,242 outputs
Outputs of similar age
#145,489
of 160,668 outputs
Outputs of similar age from BMC Cancer
#51
of 61 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,242 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,668 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.