Title |
siRNA against presenilin 1 (PS1) down regulates amyloid β42 production in IMR-32 cells
|
---|---|
Published in |
Journal of Biomedical Science, January 2012
|
DOI | 10.1186/1423-0127-19-2 |
Pubmed ID | |
Authors |
Ramesh JL Kandimalla, Willayat Yousuf Wani, Binukumar BK, Kiran Dip Gill |
Abstract |
One of the pathological hallmarks of Alzheimer's disease (AD) is the deposition of the ~4 kDa amyloid β protein (Aβ) within lesions known as senile plaques. Aβ is also deposited in the walls of cerebral blood vessels in many cases of AD. A substantial proportion of the Aβ that accumulates in the AD brain is deposited as Amyloid, which is highly insoluble, proteinaceous material with a β-pleated-sheet conformation and deposited extracellularly in the form of 5-10 nm wide straight fibrils. As γ-secretase catalyzes the final cleavage that releases the Aβ42 or 40 from amyloid β -protein precursor (APP), therefore, it is a potential therapeutic target for the treatment of AD. γ-Secretase cleavage is performed by a high molecular weight protein complex containing presenilins (PSs), nicastrin, Aph-1 and Pen-2. Previous studies have demonstrated that the presenilins (PS1 and PS2) are critical components of a large enzyme complex that performs γ-secretase cleavage. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 21% |
Student > Ph. D. Student | 4 | 17% |
Student > Bachelor | 3 | 13% |
Student > Master | 2 | 8% |
Other | 2 | 8% |
Other | 3 | 13% |
Unknown | 5 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 21% |
Neuroscience | 4 | 17% |
Agricultural and Biological Sciences | 3 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Social Sciences | 1 | 4% |
Other | 3 | 13% |
Unknown | 6 | 25% |