Title |
miRNA-135a promotes breast cancer cell migration and invasion by targeting HOXA10
|
---|---|
Published in |
BMC Cancer, March 2012
|
DOI | 10.1186/1471-2407-12-111 |
Pubmed ID | |
Authors |
Yating Chen, Jin Zhang, Huijun Wang, Jiayi Zhao, Cheng Xu, Yingying Du, Xin Luo, Fengyun Zheng, Rui Liu, Hongwei Zhang, Duan Ma |
Abstract |
miRNAs are a group of small RNA molecules regulating target genes by inducing mRNA degradation or translational repression. Aberrant expression of miRNAs correlates with various cancers. Although miR-135a has been implicated in several other cancers, its role in breast cancer is unknown. HOXA10 however, is associated with multiple cancer types and was recently shown to induce p53 expression in breast cancer cells and reduce their invasive ability. Because HOXA10 is a confirmed miR-135a target in more than one tissue, we examined miR-135a levels in relation to breast cancer phenotypes to determine if miR-135a plays role in this cancer type. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 38% |
Italy | 1 | 13% |
United Kingdom | 1 | 13% |
Canada | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 1% |
United States | 1 | 1% |
Unknown | 65 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 16 | 24% |
Researcher | 11 | 16% |
Student > Ph. D. Student | 10 | 15% |
Student > Doctoral Student | 7 | 10% |
Lecturer | 5 | 7% |
Other | 10 | 15% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 30% |
Biochemistry, Genetics and Molecular Biology | 17 | 25% |
Medicine and Dentistry | 13 | 19% |
Neuroscience | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Other | 4 | 6% |
Unknown | 9 | 13% |