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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Beyond comparisons of means: understanding changes in gene expression at the single-cell level
|
|---|---|
| Published in |
Genome Biology, April 2016
|
| DOI | 10.1186/s13059-016-0930-3 |
| Pubmed ID | |
| Authors |
Catalina A. Vallejos, Sylvia Richardson, John C. Marioni |
| Abstract |
Traditional differential expression tools are limited to detecting changes in overall expression, and fail to uncover the rich information provided by single-cell level data sets. We present a Bayesian hierarchical model that builds upon BASiCS to study changes that lie beyond comparisons of means, incorporating built-in normalization and quantifying technical artifacts by borrowing information from spike-in genes. Using a probabilistic approach, we highlight genes undergoing changes in cell-to-cell heterogeneity but whose overall expression remains unchanged. Control experiments validate our method's performance and a case study suggests that novel biological insights can be revealed. Our method is implemented in R and available at https://github.com/catavallejos/BASiCS . |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 19% |
| United States | 5 | 19% |
| Canada | 2 | 7% |
| Australia | 1 | 4% |
| Spain | 1 | 4% |
| Ireland | 1 | 4% |
| Switzerland | 1 | 4% |
| Germany | 1 | 4% |
| France | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 8 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 17 | 63% |
| Members of the public | 8 | 30% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 330 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 2% |
| United Kingdom | 5 | 2% |
| Spain | 2 | <1% |
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Germany | 1 | <1% |
| Denmark | 1 | <1% |
| Ghana | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 308 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 88 | 27% |
| Researcher | 80 | 24% |
| Student > Master | 29 | 9% |
| Student > Bachelor | 26 | 8% |
| Student > Postgraduate | 20 | 6% |
| Other | 49 | 15% |
| Unknown | 38 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 110 | 33% |
| Biochemistry, Genetics and Molecular Biology | 90 | 27% |
| Computer Science | 28 | 8% |
| Mathematics | 12 | 4% |
| Medicine and Dentistry | 8 | 2% |
| Other | 34 | 10% |
| Unknown | 48 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2018.
All research outputs
#1,479,260
of 25,373,627 outputs
Outputs from Genome Biology
#1,181
of 4,467 outputs
Outputs of similar age
#24,676
of 313,910 outputs
Outputs of similar age from Genome Biology
#25
of 77 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,910 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.