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Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1

Overview of attention for article published in Molecular Brain, April 2016
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2 tweeters

Citations

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27 Dimensions

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28 Mendeley
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Title
Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1
Published in
Molecular Brain, April 2016
DOI 10.1186/s13041-016-0220-8
Pubmed ID
Authors

Rachel S. White, Anup K. Bhattacharya, Yong Chen, Madeleine Byrd, Mary F. McMullen, Steven J. Siegel, Gregory C. Carlson, Sangwon F. Kim

Abstract

Activation of NMDA receptors can induce iron movement into neurons by the small GTPase Dexras1 via the divalent metal transporter 1 (DMT1). This pathway under pathological conditions such as NMDA excitotoxicity contributes to metal-catalyzed reactive oxygen species (ROS) generation and neuronal cell death, and yet its physiological role is not well understood. We found that genetic and pharmacological ablation of this neuronal iron pathway in the mice increased glutamatergic transmission. Voltage sensitive dye imaging of hippocampal slices and whole-cell patch clamping of synaptic currents, indicated that the increase in excitability was due to synaptic modification of NMDA receptor activity via modulation of the PKC/Src/NR2A pathway. Moreover, we identified that lysosomal iron serves as a main source for intracellular iron signaling modulating glutamatergic excitability. Our data indicates that intracellular iron is dynamically regulated in the neurons and robustly modulate synaptic excitability under physiological condition. Since NMDA receptors play a central role in synaptic neurophysiology, plasticity, neuronal homeostasis, neurodevelopment as well as in the neurobiology of many diseases, endogenous iron is therefore likely to have functional relevance to each of these areas.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 25%
Researcher 5 18%
Student > Bachelor 4 14%
Professor > Associate Professor 3 11%
Student > Master 2 7%
Other 4 14%
Unknown 3 11%
Readers by discipline Count As %
Neuroscience 5 18%
Medicine and Dentistry 5 18%
Agricultural and Biological Sciences 4 14%
Biochemistry, Genetics and Molecular Biology 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 5 18%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2016.
All research outputs
#3,471,219
of 7,588,328 outputs
Outputs from Molecular Brain
#205
of 417 outputs
Outputs of similar age
#112,835
of 245,094 outputs
Outputs of similar age from Molecular Brain
#24
of 40 outputs
Altmetric has tracked 7,588,328 research outputs across all sources so far. This one has received more attention than most of these and is in the 52nd percentile.
So far Altmetric has tracked 417 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,094 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.