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Mendeley readers
Attention Score in Context
| Title |
Altered intrinsic insular activity predicts symptom severity in unmedicated obsessive-compulsive disorder patients: a resting state functional magnetic resonance imaging study
|
|---|---|
| Published in |
BMC Psychiatry, April 2016
|
| DOI | 10.1186/s12888-016-0806-9 |
| Pubmed ID | |
| Authors |
Yajing Zhu, Qing Fan, Haiyin Zhang, Jianyin Qiu, Ling Tan, Zeping Xiao, Shanbao Tong, Jue Chen, Yao Li |
| Abstract |
Previous neuroimaging data indicated that the dysfunction in cortico-striato-thalamo-cortical (CSTC) circuit contributed to the neuropathological mechanism of obsessive-compulsive disorder (OCD). Whereas, emerging work has shown that the pathophysiology of OCD might be related to more widely distributed large-scale brain systems including limbic system and the salience network. This study aims to investigate the aberrant spontaneous neuronal activity within the whole brain, and its association with the symptom severity for unmedicated OCD patients. Twenty-eight unmedicated OCD adults and twenty-eight matched healthy controls were recruited for a resting state functional magnetic resonance imaging (fMRI) study. The amplitude of low-frequency fluctuation (ALFF) analysis over whole brain was performed to examine the intrinsic cerebral activity of subjects. In addition, we conducted the voxel-based Pearson's correlative analysis to probe into the relationship between ALFF values and symptom severity for OCD patients. Our results showed that OCD patients had increased ALFF measures in the left frontopolar cortex and left orbital frontal cortex (OFC), with decreased ALFF values in the right insula. Moreover, the right insular intrinsic activity was significantly correlated with total YBOCS score (r = 0.611, p = 0.002) and compulsion score (r = 0.640, p = 0.001) for OCD patients. The results showed abnormal intrinsic neuronal activity within CSTC circuit and salience network of OCD patients. Our finding of aberrant insular activity advanced the understanding of OCD pathophysiology beyond the traditional CSTC circuit. To the best of our knowledge, it is the first finding about a reduced insular activity at the resting state for unmedicated OCD patients, which might serve as an informative biomarker for OCD pathophysiology. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| France | 1 | 1% |
| Unknown | 66 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 26% |
| Student > Bachelor | 12 | 18% |
| Student > Master | 10 | 15% |
| Researcher | 8 | 12% |
| Other | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 13 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 18 | 26% |
| Neuroscience | 16 | 24% |
| Agricultural and Biological Sciences | 3 | 4% |
| Medicine and Dentistry | 3 | 4% |
| Social Sciences | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 22 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2016.
All research outputs
#19,292,491
of 23,881,329 outputs
Outputs from BMC Psychiatry
#4,109
of 4,939 outputs
Outputs of similar age
#201,565
of 271,971 outputs
Outputs of similar age from BMC Psychiatry
#86
of 102 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,939 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.9. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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