Title |
Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients
|
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Published in |
Journal of Neuroinflammation, January 2010
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DOI | 10.1186/1742-2094-7-5 |
Pubmed ID | |
Authors |
Shawn G Rhind, Naomi T Crnko, Andrew J Baker, Laurie J Morrison, Pang N Shek, Sandro Scarpelini, Sandro B Rizoli |
Abstract |
Traumatic brain injury (TBI) initiates interrelated inflammatory and coagulation cascades characterized by wide-spread cellular activation, induction of leukocyte and endothelial cell adhesion molecules and release of soluble pro/antiinflammatory cytokines and thrombotic mediators. Resuscitative care is focused on optimizing cerebral perfusion and reducing secondary injury processes. Hypertonic saline is an effective osmotherapeutic agent for the treatment of intracranial hypertension and has immunomodulatory properties that may confer neuroprotection. This study examined the impact of hypertonic fluids on inflammatory/coagulation cascades in isolated head injury. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Puerto Rico | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Members of the public | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 1% |
Portugal | 1 | <1% |
Canada | 1 | <1% |
Unknown | 143 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 20 | 14% |
Student > Bachelor | 17 | 12% |
Other | 13 | 9% |
Researcher | 13 | 9% |
Student > Doctoral Student | 13 | 9% |
Other | 46 | 31% |
Unknown | 25 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 66 | 45% |
Nursing and Health Professions | 12 | 8% |
Neuroscience | 12 | 8% |
Agricultural and Biological Sciences | 10 | 7% |
Psychology | 5 | 3% |
Other | 13 | 9% |
Unknown | 29 | 20% |